ea0015oc23 | Tumours, diabetes, bone | SFEBES2008
Chen Min
, Dickerson Kathryn
, Wang Jie
, Kelleher James
, Gavrilova Oksana
, Zhang Qing-Hong
, Xie Tao
, Weinstein Lee
Gsα is a ubiquitously expressed G protein α-subunit that couples receptors to adenylyl cyclase and cAMP generation. In patients with Albright hereditary osteodystrophy (AHO), heterozygous Gsα mutations only lead to obesity when present on the maternal allele. Similarly, mice with heterozygous germline Gsα mutations on the maternal allele develop severe obesity and insulin resistance with reduced energy expenditure relative t...